Article

Morphological Reprogramming of Primary Cilia Length Mitigates the Fibrotic Phenotype in Fibroblasts Across Diverse Fibrotic Conditions

2024-01-08

Abstract excerpt

<h4>ABSTRACT</h4> Fibrosis is a hallmark of systemic sclerosis (SSc) and many diverse and incurable diseases. Myofibroblast activation, a common cellular phenomenon shared across fibrotic diseases, is marked by actin polymerization known to affect primary cilia (PC) length. We discovered that fibroblasts from diverse fibrotic conditions display significantly reduced PC length ex vivo. Treatment of healthy fibrob...

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Literature Corpus work: 3941c79d-9711-54fb-be3e-91ce7abf1483
DOI: 10.1101/2024.01.06.574461

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