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Altered Ca2+ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis.

Cells - 24 Dec 2021

Buks Ralfs, Dagher Tracy, Rotordam Maria Giustina, Monedero Alonso David, Cochet Sylvie, Gautier Emilie-Fleur, Chafey Philippe, Cassinat Bruno, Kiladjian Jean-Jacques, Becker Nadine, Plo Isabelle, Egée Stéphane, El Nemer Wassim

Abstract excerpt

Over 95% of Polycythemia Vera (PV) patients carry the V617F mutation in the tyrosine kinase Janus kinase 2 (JAK2), resulting in uncontrolled erythroid proliferation and a high risk of thrombosis. Using mass spectrometry, we analyzed the RBC membrane proteome and showed elevated levels of multiple Ca2+ binding proteins as well as endoplasmic-reticulum-residing proteins in PV RBC membranes compared with RBC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35011611
DOI: 10.3390/cells11010049
PMCID: PMC8750512

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