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Article

Filamin-A is required for the incorporation of tissue factor into cell-derived microvesicles

21 Nov 2013

Abstract excerpt

We previously reported that the incorporation of tissue factor (TF) into cell-derived microvesicles (MVs) is regulated by the phosphorylation of the cytoplasmic domain of TF. Since the cytoskeletal protein filamin-A is known to bind to the cytoplasmic domain of TF in a phosphorylation-dependent manner, the involvement of filamin-A in the incorporation of TF into MVs was examined. Endothelial cells were...

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PMID: 24258684
DOI: 10.1160/th13-09-0769

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