Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells.

doi:10.1111/jth.12677

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Article

Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2014

Semeraro F, Ammollo C T, Esmon N L, Esmon C T

Abstract excerpt

BACKGROUND: Extracellular histones exert part of their prothrombotic activity through the stimulation of blood cells. Besides platelets, histones can bind to red blood cells (RBCs), which are important contributors to thrombogenesis, but little is known about the functional consequences of this interaction. OBJECTIVES: To evaluate the effect of histones on the procoagulant potential of human RBCs with particular...

Topics

Aniline Compounds
Animals
Annexin A5
Blood Coagulation
Blood Platelets
Calcium
Cattle
Coagulants
Erythrocytes
Flow Cytometry
Fluorescein-5-isothiocyanate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histones

Humans

Inflammation

Phenotype

Phosphatidylserines

Recombinant Proteins

Thromboplastin

Source

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Identifiers

PMID: 25069624
DOI: 10.1111/jth.12677
PMCID: PMC4194154

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