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Effects of Circulating HMGB-1 and Histones on Cardiomyocytes–Hemadsorption of These DAMPs as Therapeutic Strategy after Multiple Trauma

11 May 2020

Abstract excerpt

BACKGROUND AND PURPOSE: The aim of the study was to determine the effects of post-traumatically released High Mobility Group Box-1 protein (HMGB1) and extracellular histones on cardiomyocytes (CM). We also evaluated a therapeutic option to capture circulating histones after trauma, using a hemadsorption filter to treat CM dysfunction. EXPERIMENTAL APPROACH: We evaluated cell viability, calcium handling and...

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PMID: 32403440
DOI: 10.3390/jcm9051421

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