Article

Mouse V(D)J Humanization Recapitulates human-like Severe SARS-CoV-2 Immune Imprinting

2025-12-19

Abstract excerpt

<h4>Summary</h4> The mechanisms driving divergent SARS-CoV-2 immune imprinting in populations with distinct SARS-CoV-2 exposure histories remain unclear. However, conventional wild-type mouse models fail to recapitulate severe imprinting, even after potent ancestral-strain mRNA immunization, hindering imprinting-related mechanistic investigation and vaccine evaluation. Here, we surprisingly found that V(D)J-human...

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Literature Corpus work: 31913186-025c-541f-96bb-f37e28e27dad
DOI: 10.64898/2025.12.18.694353

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