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Article

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting.

Nature - 1 Jan 2024

Yisimayi Ayijiang, Song Weiliang, Wang Jing, Jian Fanchong, Yu Yuanling, Chen Xiaosu, Xu Yanli, Yang Sijie, Niu Xiao, Xiao Tianhe, Wang Jing, Zhao Lijuan, Sun Haiyan, An Ran, Zhang Na, Wang Yao, Wang Peng, Yu Lingling, Lv Zhe, Gu Qingqing, Shao Fei, Jin Ronghua, Shen Zhongyang, Xie Xiaoliang Sunney, Wang Youchun, Cao Yunlong

Abstract excerpt

The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19 vaccine compositions. However, immune imprinting induced by vaccination based on the ancestral (hereafter referred to as WT) strain would compromise the antibody response to Omicron-based boosters1-5. Vaccination strategies to counter immune imprinting are critically needed. Here we investigated the degree and dynamics of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37993710
DOI: 10.1038/s41586-023-06753-7
PMCID: PMC10764275

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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