Article

Reduced B-Cell Antigenicity of Omicron Lowers Host Serologic Response

2022-06-13

Abstract excerpt

SARS-CoV-2 Omicron variant of concern (VOC) contains fifteen mutations on the receptor binding domain (RBD), evading most neutralizing antibodies from vaccinated sera. Emerging evidence suggests that Omicron breakthrough cases are associated with substantially lower antibody titers than other VOC cases. However, the mechanism remains unclear. Here, using a novel geometric deep-learning model, we discovered that th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23b575e3-f123-51fc-8e3b-28ad2c1e7804
DOI: 10.2139/ssrn.4135731

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reduced B-Cell Antigenicity of Omicron Lowers Host Serologic ResponseDOI 10.2139/ssrn.4135731Read

Reduced antigenicity of Omicron lowers host serologic responseSemantic proximity Read

Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariantsSemantic proximity Read

Characterizing SARS-CoV-2 neutralization profiles after bivalent boosting using antigenic cartographySemantic proximity Read

Combating the SARS-CoV-2 Omicron variant with non-Omicron neutralizing antibodiesSemantic proximity Read

Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variantsSemantic proximity Read

Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strainSemantic proximity Read

Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodiesSemantic proximity Read

A Detailed Overview of SARS-CoV-2 Omicron: Its Sub-Variants, Mutations and Pathophysiology, Clinical Characteristics, Immunological Landscape, Immune Escape, and Therapies.Semantic proximity Read

Potent cross-reactive antibodies following Omicron breakthrough in vaccineesSemantic proximity Read

Repeated Omicron infection alleviates SARS-CoV-2 immune imprintingSemantic proximity Read

Steep Decline in Binding Capability of SARS-CoV-2 Omicron Variant (B.1.1.529) RBD to the Antibodies in Early COVID-19 Convalescent Sera and Inactivated Vaccine Sera.Semantic proximity Read

SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike proteinSemantic proximity Read