Article

Spatial-transcriptomics reveals unique defining molecular features of 5-aminolevulinic acid+ infiltrative tumor cells associated with glioblastoma recurrence and poor survival

2021-08-04

Abstract excerpt

<title>Abstract</title> <p>Spatiotemporal-heterogeneity originating from genomic and transcriptional variation contributes to subtype switching in GBM prior to and upon recurrence. Fluorescence-guided neurosurgical resection utilizing 5-aminolevulinic acid (5ALA) enables the isolation of infiltrative margin tumor cells (5ALA+) from a non-neoplastic background within neighboring brain parenchyma. Spatial transcrip...

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Literature Corpus work: a561ef55-3437-5456-bb90-372bb10623f4
DOI: 10.21203/rs.3.rs-780275/v1

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