Article

Multi-region biopsies and patient-derived neurosphere cultures reveal spatial divergence in glioblastoma

2026-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Intratumor heterogeneity (ITH) is one of the main reasons for the lack of effective targeted therapies for glioblastoma (GBM). Imaging-guided surgical navigation allows for tumor-wide sampling to account for variation across distant regions of the tumor, but typical drug screening is performed on cell lines derived from a single biopsy and does not account for GBM heterogeneity. Here we profiled...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 98cf5845-3911-56e7-a045-dde6ad6b2eee
DOI: 10.64898/2026.04.07.717044

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-region biopsies and patient-derived neurosphere cultures reveal spatial divergence in glioblastomaDOI 10.64898/2026.04.07.717044Read

Three-dimensional patient-derived models of glioblastoma retain intra-tumoral heterogeneitySemantic proximity Read

Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneitySemantic proximity Read

Multi-Cell Type Glioblastoma Tumor Spheroids for Evaluating Sub-Population-Specific Drug ResponseSemantic proximity Read

A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical nichesSemantic proximity Read

Glioblastoma’s Next Top Model: Novel Culture Systems for Brain Cancer Radiotherapy ResearchSemantic proximity Read

Molecular and cellular intratumoral heterogeneity in primary glioblastoma: clinical and translational implicationsSemantic proximity Read

Spatial-transcriptomics reveals unique defining molecular features of 5-aminolevulinic acid+ infiltrative tumor cells associated with glioblastoma recurrence and poor survivalSemantic proximity Read

Patient-Derived Glioma Models: From Patients to Dish to AnimalsSemantic proximity Read

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral HeterogeneitySemantic proximity Read

Radiogenomics to characterize regional genetic heterogeneity in glioblastomaSemantic proximity Read

Spatial Transcriptomics Characterisation of Radionecrotic Changes in Glioblastoma PatientsSemantic proximity Read

Longitudinal multi-omics characterization of the malignant evolution in multirelapsing glioblastomaSemantic proximity Read