Article

Spatial multi-omics defines a shared glioblastoma infiltrative signature at the resection margin

2024-11-08

Abstract excerpt

Glioblastoma (GBM) remains an untreatable disease. Understanding GBM’s infiltrative biology at the resection margin is limited, despite causing disease recurrence and progression. To address this, we generated a high-throughput single-nucleus (sn)RNA-seq and snATAC-seq multi-omic dataset from six tumors with distinct genomic drivers and combined it with spatial transcriptomics to characterize the unique molecular...

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Literature Corpus work: 89c9c8ed-3c81-580a-afa4-9599f6357f27
DOI: 10.1101/2024.11.05.621879

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