Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatially resolved transcriptomic profiles reveal unique defining molecular features of infiltrative 5ALA-metabolizing cells associated with glioblastoma recurrence

11 Jul 2023

Abstract excerpt

BACKGROUND: Spatiotemporal heterogeneity originating from genomic and transcriptional variation was found to contribute to subtype switching in isocitrate dehydrogenase-1 wild-type glioblastoma (GBM) prior to and upon recurrence. Fluorescence-guided neurosurgical resection utilizing 5-aminolevulinic acid (5ALA) enables intraoperative visualization of infiltrative tumors outside the magnetic resonance imaging...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37434262
DOI: 10.1186/s13073-023-01207-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatially resolved transcriptomic profiles reveal unique defining molecular features of infiltrative 5ALA-metabolizing cells associated with glioblastoma recurrencePMID 37434262Read ↗

Spatial-transcriptomics reveals unique defining molecular features of 5-aminolevulinic acid+ infiltrative tumor cells associated with glioblastoma recurrence and poor survivalSemantic proximity Read ↗

The Invasive Region of Glioblastoma Defined by 5ALA Guided Surgery Has an Altered Cancer Stem Cell Marker Profile Compared to Central TumourSemantic proximity Read ↗

Metabolism-based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potentialSemantic proximity Read ↗

Spatial multi-omics defines a shared glioblastoma infiltrative signature at the resection marginSemantic proximity Read ↗

Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growthSemantic proximity Read ↗

Patient-Derived Surgical samples reveal patterns of glioblastoma infiltration and tumor microenvironment at the tumor marginSemantic proximity Read ↗

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue statesSemantic proximity Read ↗

A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical nichesSemantic proximity Read ↗

Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic nicheSemantic proximity Read ↗

Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptationsSemantic proximity Read ↗

Integrative Transcriptomic and Radiogenomic Analysis Identifies a MAPT-PC-GLUD1 Low-Signature State in GlioblastomaSemantic proximity Read ↗

Spatial Multiomics Defines a Shared Tumor Infiltrative Signature at the Resection Margin in High-Grade GliomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.