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Article

Polycystin-1 regulates STAT activity by a dual mechanism.

Proceedings of the National Academy of Sciences of the United States of America - 10 May 2011

Talbot Jeffrey J, Shillingford Jonathan M, Vasanth Shivakumar, Doerr Nicholas, Mukherjee Sambuddho, Kinter Mike T, Watnick Terry, Weimbs Thomas

Abstract excerpt

Mutations in polycystin-1 (PC1) lead to autosomal-dominant polycystic kidney disease (ADPKD), a leading cause of renal failure for which no treatment is available. PC1 is an integral membrane protein, which has been implicated in the regulation of multiple signaling pathways including the JAK/STAT pathway. Here we show that membrane-anchored PC1 activates STAT3 in a JAK2-dependent manner, leading to tyrosine...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21518865
DOI: 10.1073/pnas.1103816108
PMCID: PMC3093515

Genes

STAT3
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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