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Article

Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease.

Disease models & mechanisms - 1 Sept 2016

Peda Jacqueline D, Salah Sally M, Wallace Darren P, Fields Patrick E, Grantham Connor J, Fields Timothy A, Swenson-Fields Katherine I

Abstract excerpt

Polycystic kidney disease (PKD) is characterized by slow expansion of fluid-filled cysts derived from tubules within the kidney. Cystic expansion results in injury to surrounding parenchyma and leads to inflammation, scarring and ultimately loss of renal function. Macrophages are a key element in this process, promoting cyst epithelial cell proliferation, cyst expansion and disease progression. Previously, we...

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Source

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Identifiers

PMID: 27491076
DOI: 10.1242/dmm.024745
PMCID: PMC5047688

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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