Article

cSVI-DM: a single-cell-guided, vascular-centered framework for layer-specific drug mapping in cerebral small vessel disease

2026-06-09

Abstract excerpt

<title>Abstract</title> <p> <bold>Motivation:</bold> Existing drug-screening workflows are commonly signature-first, target-first, response-prediction-first or structure-first. These strategies are effective for candidate ranking but rarely preserve the biological layer from which disease evidence originates. This is limiting for cerebral small vessel disease (cSVD), where vascular cell-state, source-to-vascula...

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Literature Corpus work: a54e4edb-ad40-5b3e-b24d-030f8f28fd04
DOI: 10.21203/rs.3.rs-9937194/v1

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