Article
Benchmarking network-based gene prioritization methods for cerebral small vessel disease.
Briefings in bioinformatics - 2 Sept 2021
Zhang Huayu, Ferguson Amy, Robertson Grant, Jiang Muchen, Zhang Teng, Sudlow Cathie, Smith Keith, Rannikmae Kristiina, Wu Honghan
Abstract excerpt
Network-based gene prioritization algorithms are designed to prioritize disease-associated genes based on known ones using biological networks of protein interactions, gene-disease associations (GDAs) and other relationships between biological entities. Various algorithms have been developed based on different mechanisms, but it is not obvious which algorithm is optimal for a specific disease. To address this...
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