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A Multi-Scale Integrative Framework Identifies THBS1 as a Master Diagnostic Hub and Prioritises Small-Molecule Therapeutics for Subarachnoid Hemorrhage

2026-08-10

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<title>Abstract</title> <p>Background Subarachnoid hemorrhage resulting from intracranial aneurysm rupture is a devastating cerebrovascular event with an exceptionally grim prognosis. Identifying the cross-scale molecular mechanisms driving quiescent aneurysmal wall degeneration may facilitate the early diagnosis of high-risk lesions and contribute to targeted medical therapy development. Methods Three transcri...

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Literature Corpus work
9d2e97f2-ff47-51d6-9954-cecd7ba4d7a4
DOI
10.21203/rs.3.rs-10304485/v1
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