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Article

Diverse functional networks of Tbx3 in development and disease.

Wiley interdisciplinary reviews. Systems biology and medicine - 1 Jan 2000

Washkowitz Andrew J, Gavrilov Svetlana, Begum Salma, Papaioannou Virginia E

Abstract excerpt

The T-box transcription factor Tbx3 plays multiple roles in normal development and disease. In order to function in different tissues and on different target genes, Tbx3 binds transcription factors or other cofactors specific to temporal or spatial locations. Examining the development of the mammary gland, limbs, and heart as well as the biology of stem cells and cancer provides insights into the diverse and...

Topics

Abnormalities, Multiple
Animals
Breast Diseases
Extremities
Heart
Humans
Mammary Glands, Human
Mutation
Myocardium
Neoplasms
Stem Cells
T-Box Domain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ulna

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Identifiers

PMID: 22334480
DOI: 10.1002/wsbm.1162
PMCID: PMC3328642

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