Article

A Common Missense Variant, W335S, in β2-Glycoprotein I (APOH) is Associated with Increased Autoantibody Levels but Reduced Venous Thromboembolism Risk

2026-03-05

Abstract excerpt

Anti-β2-glycoprotein I (anti-β2GPI) antibodies are central to the pathogenesis of antiphospholipid syndrome (APS), an autoimmune disease characterized by a strong predisposition to venous thromboembolism (VTE). In this study, we conducted a multi-ancestry genome-wide association study (GWAS) of quantitative total anti-β2GPI levels in 5,969 participants enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) a...

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Literature Corpus work: a52b6f25-866e-547e-9955-45e6cb2ab4d4
DOI: 10.64898/2026.03.04.26347632

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