Domain and residue mapping of autoantibodies to β2GPI reveals differences among antiphospholipid syndrome phenotypes.

Abstract excerpt

ABSTRACT: Antiphospholipid antibodies targeting β2-glycoprotein I (β2GPI) are a hallmark of antiphospholipid syndrome (APS), associated with an increased risk of thrombosis and pregnancy morbidity. Among these, antibodies targeting domain I (DI) are common in individuals at higher risk; however, their epitopes and prevalence among APS phenotypes remain unclear. Here, we use a large collection of 29 structurally...

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