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Article

Selected ARHGEF3 Gene Polymorphisms Associated With Platelet Hyperaggregability in Patients With Venous Thromboembolism.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Jan 2026

Alena Stryckova, Maria Skerenova, Jela Ivankova, Kristina Belakova, Lenka Lisa, Ivana Plamenova, Pavol Holly, Tomas Simurda, Dusan Dobrota, Juraj Sokol, Jan Stasko

Abstract excerpt

So called "sticky platelet syndrome" (SPS) is an inherited thrombophilic thrombocytopathy characterized by platelet hyperaggregability to low concentrations of adenosine diphosphate and/or epinephrine using light transmission aggregometry and is a recognized cause of otherwise unexplained venous thromboembolism (VTE). Variants within the ARHGEF3 gene have previously been implicated in platelet-related traits,...

Topics

Humans
Rho Guanine Nucleotide Exchange Factors
Female
Male
Polymorphism, Single Nucleotide
Venous Thromboembolism
Middle Aged
Platelet Aggregation
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42142076
DOI: 10.1177/10760296261452854
PMCID: PMC13180105

Genes

ARHGEF3
TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-42142076-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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