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The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS

16 Aug 2019

Abstract excerpt

Beta-2-Glycoprotein I (β2GPI) plays a number of essential roles throughout the body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that possess the dual capability to up and down regulate the complement and coagulation systems depending upon external stimulus. Clinically, β2GPI is the primary antigen in the autoimmune condition antiphospholipid syndrome (APS), which is typically...

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PMID: 31471128
DOI: 10.1016/j.blre.2019.100610

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