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Article

Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.

Journal of thrombosis and haemostasis : JTH - 1 Mar 2013

Athanasiadis G, Sabater-Lleal M, Buil A, Souto J C, Borrell M, Lathrop M, Watkins H, Almasy L, Hamsten A, Soria J M

Abstract excerpt

BACKGROUND: β2 -Glycoprotein I (β2 -GPI), also designated apolipoprotein H, is a 50-kDa protein that circulates in blood at high concentrations, playing important roles in autoimmune diseases, hemostasis, atherogenesis, and angiogenesis, as well as in host defense against bacteria and in protein/cellular waste removal. Plasma β2 -GPI levels have a significant genetic component (heritability of ~ 80%). OBJECTIVES:...

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Source

Identifiers

PMID: 23279374
DOI: 10.1111/jth.12120

Genes

GPI
CAD
APOH
ELF5
SCUBE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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