Article
Single nucleotide polymorphisms in the coding region of the apolipoprotein H (beta2-glycoprotein I) gene and their correlation with the protein polymorphism, anti-beta2glycoprotein I antibodies and cardiolipin binding: description of novel haplotypes and their evolution.
Annals of human genetics - 1 Jul 2004
Kamboh M Ilyas, Sanghera Dharambir K, Mehdi Haider, Nestlerode Cara S, Chen Qi, Khalifa Osama, Naqvi Asma, Manzi Susan, Bunker Clareann H
Abstract excerpt
Apolipoprotein H (APOH), also known as beta2-glycoprotein I, is a major autoantigen for the production of antiphospholipid antibodies (APA) in autoimmune diseases. APA is also recognized by a cryptic epitope generated following the interaction of APOH with anionic phospholipids (PL). The prevalence of APA in the general U.S. white population is about 10%, but it ranges from 30-70% in patients with lupus and...
Topics
- Adult
- Alleles
- Animals
- Antibodies, Anticardiolipin
- Antibodies, Antiphospholipid
- Biological Evolution
- COS Cells
- Chlorocebus aethiops
- Conserved Sequence