Article

A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP

2025-08-01

Abstract excerpt

The nascent polypeptide-associated complex (NAC) co-translationally screens all nascent proteins and regulates their access to the signal recognition particle (SRP) to ensure the fidelity of protein targeting to the endoplasmic reticulum (ER). However, the mechanism by which NAC prevents the mistargeting of nascent mitochondrial proteins remains unclear. Here, we identified a molecular switch in NAC that allows it...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5293054-2e80-5c6f-aa10-5d3ac951c71a
DOI: 10.1101/2025.07.29.667405

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A molecular switch in NAC prevents mitochondrial protein mistargeting by SRPDOI 10.1101/2025.07.29.667405Read

A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP.Semantic proximity Read

The nascent polypeptide-associated complex (NAC) promotes interaction of ribosomes with the mitochondrial surface in vivo.Semantic proximity Read

Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.Semantic proximity Read

Lost in Translation: Ribosome-Associated mRNA and Protein Quality ControlsSemantic proximity Read

Stress Response and Adaptation Mediated by Amino Acid Misincorporation during Protein Synthesis.Semantic proximity Read

An intramembrane chaperone complex facilitates membrane protein biogenesis.Semantic proximity Read

Alternative start codon selection shapes mitochondrial function during evolution, homeostasis, and diseaseSemantic proximity Read

Targeting and translocation of proteins to the endoplasmic reticulum at a glanceSemantic proximity Read

ZNF598 responds to mitochondrial stress to abort stalled translation on mitochondrial outer membrane and maintain tissue homeostasisSemantic proximity Read

A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum.Semantic proximity Read

Mechanisms of transmembrane domain recognition during endoplasmic reticulum quality controlSemantic proximity Read

Position-Dependent NMD Generates Diverse Protein OutcomesSemantic proximity Read