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Article

A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP.

Nature communications - 27 Mar 2026

Maldosevic Emir, Gora Radoslaw Jakub, Lin Liangguang Leo, Zhou Linyao Elina, Li Zexin Jason, Peskova Yelena, Qi Ling, Shan Shu-Ou, Jomaa Ahmad

Abstract excerpt

The nascent polypeptide-associated complex (NAC) co-translationally screens all nascent proteins and regulates their access to signal recognition particle (SRP) to ensure the fidelity of protein targeting to the endoplasmic reticulum (ER). However, the mechanism by which NAC prevents the mistargeting of nascent mitochondrial proteins remains unclear. Here, we identify a molecular switch in NAC that allows its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41896572
DOI: 10.1038/s41467-026-71061-3
PMCID: PMC13186951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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