Article

<i>Tff2</i> marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury

2025-04-10

Abstract excerpt

<h4>In Brief</h4> Tu et al. show that Tff2 + corpus isthmus cells are TA progenitors, and they, not chief cells, are the primary source of SPEM following injury. Upon Kras mutation, these progenitors directly progress to dysplasia, bypassing metaplasia, highlighting them as a potential origin of gastric cancer. <h4>Highlights</h4> Tff2 + corpus cells are TA progenitors that give rise to secretory cells. Tff2...

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Literature Corpus work: 7154534e-1c6a-5ec4-b73b-0b4e15973dee
DOI: 10.1101/2025.04.09.647847

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