Article

Human PARPs modify RNA nucleobases <i>in vitro</i> and in cells

2026-03-31

Abstract excerpt

<h4>SUMMARY</h4> ADP-ribosylation is known as a protein modification, yet recent studies have expanded the range of ADP-ribosyltransferase (ART) substrates to include nucleic acids. tRNA 2′-phosphotransferase 1 (TRPT1) and several PARP family members can modify the 5′-phosphate of single-stranded RNA. Here, we show that PARP10 and PARP15 extend this activity beyond the 5′-phosphate terminus and generate N3-ADP-ri...

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Literature Corpus work: a501dd7d-8a0f-5b42-bf29-85ddac4e1749
DOI: 10.64898/2026.03.31.715305

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