Article
A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene.
Molecular cell - 7 Dec 2017
Singh Hari R, Nardozza Aurelio P, Möller Ingvar R, Knobloch Gunnar, Kistemaker Hans A V, Hassler Markus, Harrer Nadine, Blessing Charlotte, Eustermann Sebastian, Kotthoff Christiane, Huet Sébastien, Mueller-Planitz Felix, Filippov Dmitri V, Timinszky Gyula, Rand Kasper D, Ladurner Andreas G
Abstract excerpt
DNA damage triggers chromatin remodeling by mechanisms that are poorly understood. The oncogene and chromatin remodeler ALC1/CHD1L massively decompacts chromatin in vivo yet is inactive prior to DNA-damage-mediated PARP1 induction. We show that the interaction of the ALC1 macrodomain with the ATPase module mediates auto-inhibition. PARP1 activation suppresses this inhibitory interaction. Crucially, release from...
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