Article
Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk.
Psychological medicine - 1 Oct 2023
Zhang Chengcheng, Li Xiaojing, Zhao Liansheng, Guo Wanjun, Deng Wei, Wang Qiang, Hu Xun, Du Xiangdong, Sham Pak Chung, Luo Xiongjian, Li Tao
Abstract excerpt
BACKGROUND: To identify risk genes whose expression are regulated by the reported risk variants and to explore the potential regulatory mechanism in schizophrenia (SCZ). METHODS: We systematically integrated three independent brain expression quantitative traits (eQTLs) (CommonMind, GTEx, and BrainSeq Phase 2, a total of 1039 individuals) and GWAS data (56 418 cases and 78 818 controls), with the use of...
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