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Article

S-adenosylhomocysteine Hydrolase Participates in DNA Methylation Inheritance.

Journal of molecular biology - 6 Jul 2018

Ponnaluri V K Chaithanya, Estève Pierre-Olivier, Ruse Cristian I, Pradhan Sriharsa

Abstract excerpt

DNA (cytosine-5) methyltransferase 1 (DNMT1) is essential for mammalian development and maintenance of DNA methylation following DNA replication in cells. The DNA methylation process generates S-adenosyl-l-homocysteine, a strong inhibitor of DNMT1. Here we report that S-adenosylhomocysteine hydrolase (SAHH/AHCY), the only mammalian enzyme capable of hydrolyzing S-adenosyl-l-homocysteine binds to DNMT1 during DNA...

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Source

Identifiers

PMID: 29758262
DOI: 10.1016/j.jmb.2018.05.014

Genes

DNMT1
AHCY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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