Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Metabolic Function for Phospholipid and Histone Methylation.

Molecular cell - 20 Apr 2017

Ye Cunqi, Sutter Benjamin M, Wang Yun, Kuang Zheng, Tu Benjamin P

Abstract excerpt

S-adenosylmethionine (SAM) is the methyl donor for biological methylation modifications that regulate protein and nucleic acid functions. Here, we show that methylation of a phospholipid, phosphatidylethanolamine (PE), is a major consumer of SAM. The induction of phospholipid biosynthetic genes is accompanied by induction of the enzyme that hydrolyzes S-adenosylhomocysteine (SAH), a product and inhibitor of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine
Share to Energy Metabolism
Share to Lysine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Methylation

Share to Phosphatidylcholines

Share to Phosphatidylethanolamines

Share to Protein Phosphatase 2

Share to S-Adenosylmethionine

Source

Open in PubMed Open full text

Identifiers

PMID: 28366644
DOI: 10.1016/j.molcel.2017.02.026
PMCID: PMC5482412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Metabolic Function for Phospholipid and Histone Methylation.PMID 28366644Read ↗

Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress SurvivalSemantic proximity Read ↗

Epigenetics and Cellular MetabolismSemantic proximity Read ↗

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.Semantic proximity Read ↗

Choline transport activity regulates phosphatidylcholine synthesis through choline transporter Hnm1 stability.Semantic proximity Read ↗

Accumulation of S-adenosyl-L-homocysteine impairs methylation and development in Saccharomyces cerevisiae and Drosophila melanogasterSemantic proximity Read ↗

Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms.Semantic proximity Read ↗

The methyl cycle is a conserved regulator of biological clocksSemantic proximity Read ↗

Expanding and Decoding the Chemistry of Phospholipid Headgroup in EukaryotesSemantic proximity Read ↗

Protein methylation functions as the posttranslational modification switch to regulate autophagySemantic proximity Read ↗

The impact of metabolism on DNA methylationSemantic proximity Read ↗

Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expressionSemantic proximity Read ↗

Choline metabolitesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.