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Article

Homocysteine regulates fatty acid and lipid metabolism in yeast.

The Journal of biological chemistry - 13 Apr 2018

Visram Myriam, Radulovic Maja, Steiner Sabine, Malanovic Nermina, Eichmann Thomas O, Wolinski Heimo, Rechberger Gerald N, Tehlivets Oksana

Abstract excerpt

S-Adenosyl-l-homocysteine hydrolase (AdoHcy hydrolase; Sah1 in yeast/AHCY in mammals) degrades AdoHcy, a by-product and strong product inhibitor of S-adenosyl-l-methionine (AdoMet)-dependent methylation reactions, to adenosine and homocysteine (Hcy). This reaction is reversible, so any elevation of Hcy levels, such as in hyperhomocysteinemia (HHcy), drives the formation of AdoHcy, with detrimental consequences...

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Source

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Identifiers

PMID: 29414770
DOI: 10.1074/jbc.M117.809236
PMCID: PMC5900771

Genes

AHCY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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