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Article

Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability.

G3 (Bethesda, Md.) - 6 Nov 2015

Liu Mengying, Barnes Valerie L, Pile Lori A

Abstract excerpt

Histone methylation levels, which are determined by the action of both histone demethylases and methyltransferases, impact multiple biological processes by affecting gene expression activity. Methionine metabolism generates the major methyl donor S-adenosylmethionine (SAM) for histone methylation. The functions of methionine metabolic enzymes in regulating biological processes as well as the interaction between...

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PMID: 26546310
DOI: 10.1534/g3.115.024273
PMCID: PMC4704710

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