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Homocysteine Thiolactone Detoxifying Enzymes and Alzheimer’s Disease

2024-06-05

Abstract excerpt

Elevated levels of homocysteine (Hcy) and related metabolites are associated with Alzheimer’s disease (AD). Severe hyperhomocysteinemia causes neurological deficits and worsens behavioral and biochemical traits associated with AD. Although Hcy is precluded from entering the Genetic Code by proofreading mechanisms of aminoacyl-tRNA synthetases, and thus is a non-protein amino acid, it can be attached to prote...

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Literature Corpus work
9d09f76d-625c-5f63-828e-80a8e30fa9a9
DOI
10.20944/preprints202406.0219.v1
Open publication

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