Article

A Phase II Trial of ADI-PEG20 in Combination with Gemcitabine and Docetaxel for the Treatment of Soft Tissue Sarcoma

2026-08-06

Abstract excerpt

<title>Abstract</title> <p>Background Arginine deprivation with pegylated arginine deiminase (ADI-PEG 20, pegargiminase) may enhance chemotherapy efficacy in soft tissue sarcomas (STS). We conducted a phase II trial (NCT03449901) evaluating ADI-PEG20 plus gemcitabine/docetaxel in advanced STS. Methods Seventy-five evaluable patients received ADI-PEG20 with gemcitabine/docetaxel across three dose cohorts. Correl...

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Literature Corpus work: a4a5fe76-4595-5cad-bc30-0b242b6062d5
DOI: 10.21203/rs.3.rs-10020463/v1

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A Phase II Trial of ADI-PEG20 in Combination with Gemcitabine and Docetaxel for the Treatment of Soft Tissue SarcomaDOI 10.21203/rs.3.rs-10020463/v1Read

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