Article

Metabolomic reprogramming of the tumor microenvironment by dual arginase inhibitor OATD-02 boosts anticancer immunity

2025-04-01

Abstract excerpt

<title>Abstract</title> <p>Metabolic reprogramming within the tumor microenvironment (TME) plays a central role in cancer progression and immune evasion, with L-arginine metabolism emerging as a key regulatory axis. Arginase overexpression depletes intratumoral L-arginine, thus suppressing T-cell proliferation while fuelling tumor growth through polyamine biosynthesis. OATD-02, a novel dual arginase (ARG1/ARG2) i...

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Literature Corpus work: 3106b9f1-f8a5-5338-90f7-d29bf22cc274
DOI: 10.21203/rs.3.rs-6305179/v1

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