Article

SMARCB1 Deficiency as a Driver of the Hallmarks of Cancer in Rhabdoid Tumours: Novel Insights into Dysregulated Energy Metabolism, Emerging Targets, and Ongoing Clinical Trials

2025-04-07

Abstract excerpt

Rhabdoid tumours (RTs) are aggressive neoplasms most often characterised by biallelic loss of the SMARCB1 gene, which encodes a core subunit of the SWI/SNF chromatin remodelling complex. Despite their relative genetic stability, RTs exhibit a highly malignant phenotype and poor prognosis. This review aims to explore the mechanisms underlying SMARCB1 aberrations, their role in driving hallmarks of cancer, and emerg...

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Literature Corpus work: 6648e4d0-08f8-5c2a-8e96-80f78d24054f
DOI: 10.20944/preprints202504.0582.v1

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SMARCB1 Deficiency as a Driver of the Hallmarks of Cancer in Rhabdoid Tumours: Novel Insights into Dysregulated Energy Metabolism, Emerging Targets, and Ongoing Clinical TrialsDOI 10.20944/preprints202504.0582.v1Read

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