ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance.

doi:10.1158/1078-0432.CCR-12-2641

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Article

ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2013

Huang Hsuan-Ying, Wu Wen-Ren, Wang Yu-Hui, Wang Jun-Wen, Fang Fu-Min, Tsai Jen-Wei, Li Shau-Hsuan, Hung Hsiao-Chin, Yu Shih-Chen, Lan Jui, Shiue Yow-Ling, Hsing Chung-His, Chen Li-Tzong, Li Chien-Feng

Abstract excerpt

PURPOSE: The principal goals were to identify and validate targetable metabolic drivers relevant to myxofibrosarcoma pathogenesis using a published transcriptome. EXPERIMENTAL DESIGN: As the most significantly downregulated gene regulating amino acid metabolism, argininosuccinate synthetase (ASS1) was selected for further analysis by methylation-specific PCR, pyrosequencing, and immunohistochemistry of...

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PMID: 23549872
DOI: 10.1158/1078-0432.CCR-12-2641

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ASS1

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