Article

Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia condition

2022-11-22

Abstract excerpt

<h4>Background: </h4> & Aims: Cisplatin (DDP)-based chemotherapy is commonly adopted as the first-line treatment for patients with oesophageal squamous cell carcinoma (OSCC), but the high rate of drug resistance limits its clinical application, and the underlying mechanisms remain unclear. The aims of this study is to elucidate the role of abnormal signal transmission and metabolism in chemoresistance of OSCC unde...

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Literature Corpus work: 63f25ce0-ef9a-57c0-82b5-ec50654a5f6e
DOI: 10.21203/rs.3.rs-2269651/v1

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