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Article

Succinylation-related molecular activities in cancer: metabolic adaptations, immune landscape, and prognostic significance in colorectal cancer

20 May 2025

Abstract excerpt

Background Succinylation, a key post-translational modification, plays a crucial role in metabolic regulation and tumor progression. However, its influence on the tumor immune microenvironment and its prognostic implications remain unclear. A systematic pan-cancer analysis of succinylation-related molecular activities is needed. Methods Bulk transcriptomic, single-cell RNA sequencing, and spatial transcriptomic...

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PMID: 40463370
DOI: 10.3389/fimmu.2025.1571446

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