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TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types

9 May 2018

Abstract excerpt

Stress granules (SGs) are cytoplasmic foci that form in response to various external stimuli and are essential to cell survival following stress. SGs are studied in several diseases, including ALS and FTD, which involve the degeneration of motor and cortical neurons, respectively, and are now realized to be linked pathogenically by TDP-43, originally discovered as a component of ubiquitin-positive aggregates...

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PMID: 29765078
DOI: 10.1038/s41598-018-25767-0

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