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Stress granule assemblyin vivois deficient in the CNS of mutant TDP-43 ALS mice

22 Aug 2022

Abstract excerpt

Responding effectively to external stress is crucial for neurons. Defective stress granule dynamics has been hypothesized as one of the pathways that renders motor neurons in amyotrophic lateral sclerosis (ALS) more prone to early death. Specifically, it is thought that stress granules seed the cytoplasmic TDP-43 inclusions that are observed in the neurons of most ALS patients, as well as ~50% of all...

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PMID: 35994036
DOI: 10.1093/hmg/ddac206

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