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Article

Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation.

Cell stress & chaperones - 1 Nov 2017

Zeineddine Rafaa, Farrawell Natalie E, Lambert-Smith Isabella A, Yerbury Justin J

Abstract excerpt

ALS is characterised by a focal onset of motor neuron loss, followed by contiguous outward spreading of pathology throughout the nervous system, resulting in paralysis and death generally within a few years after diagnosis. The aberrant release and uptake of toxic proteins including SOD1 and TDP-43 and their subsequent propagation, accumulation and deposition in motor neurons may explain such a pattern of...

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Identifiers

PMID: 28560609
DOI: 10.1007/s12192-017-0804-y
PMCID: PMC5655364

Genes

SOD1

Variants

Provenance

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