Article
ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation.
PloS one - 1 Jan 2013
Walker Adam K, Soo Kai Y, Sundaramoorthy Vinod, Parakh Sonam, Ma Yi, Farg Manal A, Wallace Robyn H, Crouch Peter J, Turner Bradley J, Horne Malcolm K, Atkin Julie D
Abstract excerpt
In amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration, TAR DNA binding protein 43 (TDP-43) accumulates in the cytoplasm of affected neurons and glia, where it associates with stress granules (SGs) and forms large inclusions. SGs form in response to cellular stress, including endoplasmic reticulum (ER) stress, which is induced in both familial and sporadic forms of ALS. Here we demonstrate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.