Article
Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease.
Neurochemical research - 1 Oct 2021
Salcedo Claudia, Wagner Antonie, Andersen Jens V, Vinten Kasper Tore, Waagepetersen Helle S, Schousboe Arne, Freude Kristine K, Aldana Blanca I
Abstract excerpt
Alterations in neurotransmitter homeostasis, primarily of glutamate and GABA, is strongly implicated in the pathophysiology of Alzheimer's disease (AD). Homeostasis at the synapse is maintained by neurotransmitter recycling between neurons and astrocytes. Astrocytes support neuronal transmission through glutamine synthesis, which can be derived from oxidative metabolism of GABA. However, the precise implications...
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