Article

Whole-exome sequencing of plasma cell-free DNA portrays the somatic mutation landscape of refractory metastatic colorectal cancer and enables the discovery of mutated <i>KDR</i> /VEGFR2 receptors as modulators of anti-angiogenic therapies

2017-08-17

Abstract excerpt

<h4>ABSTRACT</h4> The non-invasive detection of cancer mutations is a breakthrough in oncology. Here, we applied whole-exome sequencing of matched germline and basal plasma cell-free DNA samples (WES-cfDNA) on a RAS/BRAF/PIK3CA wild-type metastatic colorectal cancer patient with primary resistance to standard treatment regimens including VEGFR inhibitors. Using WES-cfDNA, we could detect 73% (54/74) of the somat...

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Literature Corpus work: a456ff1d-a5a3-5b8c-9d08-3db3e6a16973
DOI: 10.1101/177287

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