Article
Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer.
Cancer discovery - 1 Feb 2018
Strickler John H, Loree Jonathan M, Ahronian Leanne G, Parikh Aparna R, Niedzwiecki Donna, Pereira Allan Andresson Lima, McKinney Matthew, Korn W Michael, Atreya Chloe E, Banks Kimberly C, Nagy Rebecca J, Meric-Bernstam Funda, Lanman Richard B, Talasaz AmirAli, Tsigelny Igor F, Corcoran Ryan B, Kopetz Scott
Abstract excerpt
"Liquid biopsy" approaches analyzing cell-free DNA (cfDNA) from the blood of patients with cancer are increasingly utilized in clinical practice. However, it is not yet known whether cfDNA sequencing from large cohorts of patients with cancer can detect genomic alterations at frequencies similar to those observed by direct tumor sequencing, and whether this approach can generate novel insights. Here, we report...
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