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Article

Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jan 2023

Topham James T, O'Callaghan Chris J, Feilotter Harriet, Kennecke Hagen F, Lee Young S, Li Weimin, Banks Kimberly C, Quinn Katie, Renouf Daniel J, Jonker Derek J, Tu Dongsheng, Chen Eric X, Loree Jonathan M

Abstract excerpt

PURPOSE: Anti-epidermal growth factor receptor (EGFR) antibodies are effective treatments for metastatic colorectal cancer. Improved understanding of acquired resistance mechanisms may facilitate circulating tumor DNA (ctDNA) monitoring, anti-EGFR rechallenge, and combinatorial strategies to delay resistance. METHODS: Patients with treatment-refractory metastatic colorectal cancer (n = 169) enrolled on the CO.26...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36007218
DOI: 10.1200/JCO.22.00364
PMCID: PMC9870216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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