Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies.

doi:10.1158/1078-0432.CCR-18-0103

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Article

Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2018

Toledo Rodrigo A, Garralda Elena, Mitsi Maria, Pons Tirso, Monsech Jorge, Vega Estela, Otero Álvaro, Albarran Maria I, Baños Natalia, Durán Yolanda, Bonilla Victoria, Sarno Francesca, Camacho-Artacho Marta, Sanchez-Perez Tania, Perea Sofia, Álvarez Rafael, De Martino Alba, Lietha Daniel, Blanco-Aparicio Carmen, Cubillo Antonio, Domínguez Orlando, Martínez-Torrecuadrada Jorge L, Hidalgo Manuel

Abstract excerpt

Purpose: Despite the wide use of antiangiogenic drugs in the clinical setting, predictive biomarkers of response to these drugs are still unknown.Experimental Design: We applied whole-exome sequencing of matched germline and basal plasma cell-free DNA samples (WES-cfDNA) on a RAS/BRAF/PIK3CA wild-type metastatic colorectal cancer patient with primary resistance to standard treatment regimens, including inhibitors...

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PMID: 29588308
DOI: 10.1158/1078-0432.CCR-18-0103

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ABL1
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